A Multicenter, Double-blind, Long Term Extension Study to Assess the Safety and Efficacy of Filgotinib in Subjects with Rheumatoid Arthritis
The purpose of this study is to see if filgotinib can be safe and useful in the long-term treatment of RA. During this study, you will be assigned to one of two study drug dose groups as…
- Investigator
- Gurjit Kaeley
- IRB Number
- 20180717
- Sexes
- All
- Location
- Jacksonville
Uptravi® (SelexiPag): tHe usErs dRug rEgistry (SPHERE) Registry Uptravi® (Selexipag) Users Registry PROTOCOL: AC-065A402
The purpose of this Study is to better understand the demographic and clinical characteristics of PAH patients treated with Uptravi, to learn about the dosing and titration patterns of Uptravi…
- Investigator
- Vandana Seeram
- IRB Number
- 20162037
- Location
- Jacksonville
OPEN ENROLLMENT
Pragmatic evaluation of events and benefits of Lipid-lowering in older adults (PREVENTABLE)
The PREVENTABLE trial aims to find out if a drug called atorvastatin (brand name Lipitor) can help older adults 75 years or older live well for longer by preventing dementia, disability, or heart…
- Investigator
- Arshag Mooradian
- IRB Number
- CED000000393
- Ages
- 75 Years – 100 Years
- Sexes
- All
- Location
- Jacksonville
OPEN ENROLLMENT
A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 2 Study to Investigate the Efficacy and Safety of Asapiprant in Hospitalized Adults With COVID-19
Individuals diagnosed with COVID-19 are being asked to take part in a research study of an investigational drug called Asapiprant (BGE 175). This drug is being tested for the…
- Investigator
- Carmen Isache
- IRB Number
- 20210252
- Location
- Jacksonville
OPEN ENROLLMENT
VANTAGE study
The purpose of this clinical research study is to learn more about the use of the investigational study drug, volixibat, for the treatment of pruritus (itching) associated with PBC….
- Investigator
- Neha Agrawal
- IRB Number
- 1328153
- Ages
- 18 Years – NA
- Sexes
- All
- Location
- Jacksonville
A randomised, double-blind, placebo-controlled, parallel group, dose-finding study evaluating efficacy, safety and tolerability of BI 1291583 qd over at least 24 weeks in patients with bronchiectasis. (20222253)
A study to test whether different doses of BI 1291583 help people with bronchiectasis. This study is being done to test the study drug, BI 1291583, for safety, effectiveness, and side effects, when…
- Investigator
- Mehdi Mirsaeidi
- IRB Number
- 1332722
- Location
- Jacksonville
OPEN ENROLLMENT
An Open-label Extension Study of Inhaled Treprostinil in Subjects with Fibrotic Lung Disease (20212063)
This study is investigating long-term treatment with a drug called inhaled treprostinil (brand name Tyvaso®) in people with Idiopathic Pulmonary Fibrosis (IPF). In the study, you will receive…
- Investigator
- Vandana Seeram
- IRB Number
- 1334674
- Ages
- 40 Years – 99 Years
- Sexes
- All
- Location
- Jacksonville
OPEN ENROLLMENT
A Randomized, Double-blind, Placebo-controlled, Phase 3 Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects with Idiopathic Pulmonary Fibrosis (20210052)
In general, what is the purpose of the research, how long will you be involved? You are being asked to be in this research study because you have idiopathic pulmonary fibrosis (IPF). …
- Investigator
- Vandana Seeram
- IRB Number
- 1319137
- Ages
- 40 Years – 99 Years
- Sexes
- All
- Location
- Jacksonville
OPEN ENROLLMENT
The ABCD-Gene Prospective Study
This investigation will be a prospective cohort study conducted in a population of 500 patients with stable CAD undergoing elective PCI treated with standard of care clopidogrel. By integrating…
- Investigator
- Francesco Franchi
- IRB Number
- IRB202200298
- Ages
- 18 Years
- Sexes
- All
- Location
- Jacksonville
OPEN ENROLLMENT
TAILOR BLEED
The purpose of this study is to evaluate the feasibility of switching patients from the standard dual antiplatelet therapy (DAPT) to single therapy of Ticagrelor or Prasugrel only or DAPT with…
- Investigator
- Dominick Angiolillo
- IRB Number
- IRB202202835
- Location
- Jacksonville
OPEN ENROLLMENT
Selatogrel Outcome Study in suspected Acute Myocardial Infarction (SOS-AMI)
Multi-center, double-blind, randomized, placebo-controlled, parallel-group study to evaluate the efficacy and safety of self-administered subcutaneous selatogrel for prevention of all-cause death and…
- Investigator
- Francesco Franchi
- IRB Number
- 1318659
- Ages
- 18 Years
- Sexes
- All
- Location
- Jacksonville
A randomized, double-blind, placebo-controlled, multicenter trial, assessing the impact of inclisiran on major adverse cardiovascular events in participants with established cardiovascular disease (VICTORION-2 PREVENT) (20216310)
This study is being done to find out if the investigational study treatment, called inclisiran, can help prevent cardiovascular events (such as heart attacks, strokes, and cardiovascular-related…
- Investigator
- Francesco Franchi
- IRB Number
- 1331797
- Ages
- 40 Years
- Sexes
- All
- Location
- Jacksonville
Ocean(a)
This study is being done to learn more about olpasiran (AMG 890) in people with cardiovascular disease and elevated Lp(a). It will see if olpasiran (AMG 890) reduces cardiovascular events, lowers…
- Investigator
- Francesco Franchi
- IRB Number
- 1347686
- Ages
- 18 Years – 85 Years
- Sexes
- All
- Location
- Jacksonville
OPEN ENROLLMENT
EVOLVE-MI
This study is being done to learn whether regular healthcare, combined with early treatment with a cholesterol lowering drug called evolocumab (Repatha®) reduces heart attack, stroke,…
- Investigator
- Francesco Franchi
- IRB Number
- 1348573
- Ages
- 18 Years
- Sexes
- All
- Location
- Jacksonville
CGUARD
This clinical trial is being done to help evaluate a new investigational device to treat narrowing of the carotid arteries in the neck. The device is called the CGUARD Prime Carotid Stent…
- Investigator
- Daniel Soffer
- IRB Number
- 1334311
- Ages
- 18 Years
- Sexes
- All
- Location
- Jacksonville
A randomised, double-blind, placebo-controlled, parallel group, dose-finding study evaluating efficacy, safety and tolerability of BI 1291583 qd over at least 24 weeks in patients with bronchiectasis (Airleaf™)
A study to test whether different doses of BI 1291583 help people with bronchiectasis. If you join this study, you may receive the study drug being tested, BI 1291583, and/or placebo. The study drug…
- Investigator
- Mehdi Mirsaeidi
- IRB Number
- 1397-0012
- Ages
- 18 Years – 100 Years
- Sexes
- All
- Location
- Jacksonville
Comparative effectiveness of early vs. late initiation of dialysis in chronic kidney disease stage 5 with eGFR = 10
A large multicenter randomized-controlled multi-level effectiveness-implementation emphasis pragmatic trial to evaluate the comparative effectiveness of early initiation of dialysis with eGFR at 10…
- Investigator
- Alaa Awad
- IRB Number
- N/A
- Ages
- 18 Years – 100 Years
- Sexes
- All
- Location
- Jacksonville
A 52-week study assessing exacerbation rate, asthma control and safety in adult severe eosinophilic asthmatics treated with depemokimab compared with mepolizumab or benralizumab
This is a multi-centre, randomised, double-blind, double-dummy, parallel group noninferiority trial of GSK3511294 (depemokimab) 100 mg SC compared with continuation of mepolizumab or benralizumab…
- Investigator
- Vandana Seeram
- IRB Number
- 20204289
- Sexes
- All
- Location
- Jacksonville
OPEN ENROLLMENT
The TwoPlus Study-Comparative Effectiveness of an Individualized Model of Hemodialysis vs. Conventional Hemodialysis
The purpose of this study is to compare clinical outcomes and health-related quality of life between an individualized hemodialysis prescription and conventional hemodialysis prescription in…
- Investigator
- Alaa Awad
- IRB Number
- CED000000872
- Ages
- 18 Years
- Sexes
- All
- Location
- Jacksonville
OPEN ENROLLMENT
SELECT-SLE: A Phase 3 Program to Evaluate the Safety and Efficacy of Upadacitinib in Subjects with Moderately to Severely Active SLE
The purpose of this program is to assess the safety and efficacy of upadacitinib compared with placebo (fake drug) for the treatment of signs and symptoms in adults with moderately to severely…
- Investigator
- Gurjit Kaeley
- IRB Number
- 20233520
- Ages
- 18 Years – 63 Years
- Sexes
- All
- Location
- Jacksonville
OPEN ENROLLMENT
A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Deucravacitinib in Participants with Active Systemic Lupus Erythematosus (SLE)
The POETYK SLE-1/SLE-2 (IM011-246/247) studies are two identical studies. If eligible, you will be enrolled in only one of these two studies. Participation may last between approximately 14 and 38…
- Investigator
- Gurjit Kaeley
- IRB Number
- 20232025
- Ages
- 18 Years – 75 Years
- Sexes
- All
- Location
- Jacksonville
OPEN ENROLLMENT
A Multi-Center Phase 2/3 Randomized, Double-Blind, Placebo-Controlled, Parallel- Group Safety and Efficacy Study of Dapansutrile Tablets in Subjects with an Acute Gout Flare
The main purpose of this study is to see how well dapansutrile reduces joint pain and other joint symptoms (such as tenderness and swelling) because of an acute gout flare compared with placebo. A…
- Investigator
- Gurjit Kaeley
- IRB Number
- 20224812
- Ages
- 18 Years – 100 Years
- Sexes
- All
- Location
- Jacksonville
OPEN ENROLLMENT
SAGE-PsA Study Sex- And Gender-based analysis of the Effectiveness of advanced therapies in Psoriatic Arthritis
The purpose of this study is to understand how sex and gender influence response to advanced therapies (also known as “biologic treatments”) in Psoriatic Arthritis (PsA). We hope to…
- Investigator
- Gurjit Kaeley
- IRB Number
- 202300383
- Ages
- 18 Years – 100 Years
- Sexes
- All
- Location
- Jacksonville
MAESTRO-NASH Outcomes Study
The main purpose of this study is to learn whether treatment with resmetirom compared with placebo for several years can benefit participants by slowing further disease progression and delaying…
- Investigator
- Neha Agrawal
- IRB Number
- 1353535
- Ages
- 18 Years – NA
- Sexes
- All
- Location
- Jacksonville
Effects of NNC0194-0499, cagrilintide, and semaglutide alone or in combinations on liver damage and alcohol use in people with alcohol-related liver disease
We are doing this study to look at the effects of NNC0194-0499 (alone and in fixed-dose combination with semaglutide), cagrilintide (alone and in fixed-dose combination with semaglutide called…
- Investigator
- Neha Agrawal
- IRB Number
- 1380458
- Ages
- 21 Years – NA
- Sexes
- All
- Location
- Jacksonville
OPEN ENROLLMENT
myAirvo 3 (High Flow Nasal Therapy; HFNT) for COPD patients in the home – a multi-center randomized controlled trial
The purpose of this research is to learn if home use of high flow nasal therapy (HFNT) increases the time to rehospitalization in patients with chronic obstructive pulmonary disease (COPD). You…
- Investigator
- Mehdi Mirsaeidi
- IRB Number
- 20216340
- Ages
- 30 Years – NA
- Sexes
- All
- Location
- Jacksonville
OPEN ENROLLMENT
Placebo-controlled Study to Evaluate the Efficacy and Safety of Tozorakimab in Patients Hospitalized for Viral Lung Infection Requiring Supplemental Oxygen
The purpose of this study is to find out if the experimental drug called tozorakimab is safe and effective in treating severe viral lung infections with Acute Respiratory Failure (ARF), and also to…
- Investigator
- Tracy Ashby
- IRB Number
- D9185C00001
- Ages
- 18 Years – NA
- Sexes
- All
- Location
- Jacksonville
OPEN ENROLLMENT
A Study of the Efficacy and Safety of Treatment With MNKD-101 When Added to GBT in Participants with Pulmonary Nontuberculous Mycobacterial Infection
The purpose of this study is to find out if a new investigational drug called Clofazimine Inhalation Suspension can help treat people with NTM lung disease. Part A of the study is made up of…
- Investigator
- Mehdi Mirsaeidi
- IRB Number
- 20242988
- Ages
- 18 Years – 85 Years
- Sexes
- All
- Location
- Jacksonville
OPEN ENROLLMENT
The American Lung Association (ALA) Lung Health Cohort (LHC)
The ALA-LHC is a longitudinal, multi-center cohort study that will enroll approximately 4,000 young adults between the ages of 25-35 who do not have severe lung disease. The overarching…
- Investigator
- Vandana Seeram
- IRB Number
- IRB00236497
- Ages
- 25 Years – 35 Years
- Sexes
- All
- Location
- Jacksonville
OPEN ENROLLMENT
Hypothyroidism: Efficacy and Safety of Armour Thyroid Treatment in Subjects with Primary Hypothyroidism
The purpose of this study is to evaluate if Armour Thyroid is safe and effective in the treatment of hypothyroidism. This study will compare the effect of Armour Thyroid on…
- Investigator
- Joe Chehade, Christian Koch, Payal Shooliz
- IRB Number
- P0335962
- Ages
- 18 Years – 75 Years
- Sexes
- All
- Location
- Jacksonville
OPEN ENROLLMENT
Non-invasive vagal nerve stimulation and sleep
This study is investigating if using a stimulation devise can improve quality of sleep for veterans suffering from PTSD. …
- Investigator
- Mariam Louis
- IRB Number
- 201700541
- Ages
- 18 Years – 55 Years
- Sexes
- All
- Location
- Jacksonville
OPEN ENROLLMENT
RECOVER-ENERGIZE: A Platform Protocol for Evaluation of Interventions for Exercise Intolerance in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)
RECOVER-ENERGIZE is studying possible treatments, also called study interventions, for exercise intolerance and post-exertional malaise (PEM) related to Long COVID. These studies will include…
- Investigator
- Carmen Isache, Jorge Verdecia
- IRB Number
- CED000000942
- Ages
- 18 Years – 80 Years
- Sexes
- All
- Location
- Jacksonville
OPEN ENROLLMENT
Recover SLEEP
Researchers are studying possible treatments for adults who have Long COVID, which is when a person has symptoms months after getting COVID. Symptoms can include trouble breathing, a cough, trouble…
- Investigator
- Carmen Isache
- IRB Number
- CED000000937
- Ages
- 18 Years – 75 Years
- Sexes
- All
- Location
- Jacksonville
OPEN ENROLLMENT
A Phase 2 Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study to Investigate the Safety and Efficacy of Oral Brepocitinib in Adults with Cutaneous Sarcoidosis
The purpose of this study is to measure clinical safety and efficacy of oral brepocitinib in adult participants with cutaneous…
- Investigator
- Mehdi Mirsaeidi
- IRB Number
- PVT-2201-203
- Ages
- 18 Years – 75 Years
- Sexes
- All
- Location
- Jacksonville
OPEN ENROLLMENT
Phase III Study to Evaluate the Efficacy and Safety of Tezepelumab in Adult Participants with Moderate to Very Severe Chronic Obstructive Pulmonary Disease (JOURNEY)
This study will investigate the efficacy and safety of Tezepelumab as add-on treatment to inhaled maintenance therapy in a COPD population with a history of exacerbations. This study will compare…
- Investigator
- Michael Schweitzer Barrios
- IRB Number
- D5241C00007
- Ages
- 40 Years – 80 Years
- Sexes
- All
- Location
- Jacksonville
OPEN ENROLLMENT
Phase III, randomized, double-blind, placebo-controlled study to assess BI 1291583 2.5 mg once daily for up to 76 weeks in patients with bronchiectasis
The aim of this study is to evaluate the efficacy, safety, and tolerability of BI 1291583 2.5 mg compared to placebo in participants with bronchiectasis. The ability of the study drug (BI 1291583…
- Investigator
- Mehdi Mirsaeidi, Michael Schweitzer Barrios
- IRB Number
- BI 1397-0014
- Ages
- 18 Years – 99 Years
- Sexes
- All
- Location
- Jacksonville
OPEN ENROLLMENT
The Bridging Antiplatelet Therapy with Cangrelor 2 (BRIDGE 2) Study: A Pilot Prospective Cohort, Pharmacodynamic Study of Tailored Cangrelor Bridging Dosing Regimens
This study is to determine rates of patients with optimal platelet reactivity range when using a PFT-guided titration of cangrelor infusion rate (cangrelor…
- Investigator
- Dominick Angiolillo, Luis Ortega Paz
- IRB Number
- BRIDGE 2
- Ages
- 18 Years – 99 Years
- Sexes
- All
- Location
- Jacksonville
OPEN ENROLLMENT
Switching from Clopidogrel to Low-dose Prasugrel in Patients at Dual-risk Following Percutaneous Coronary Intervention: TAILOR-BLEED-2 study
Studies have shown that the blood-thinning effects of clopidogrel can be influenced by your genetics and clinical characteristics. A scoring system called the ABCD-GENE score is used to assess…
- Investigator
- Dominick Angiolillo, Luis Ortega Paz
- IRB Number
- IRB202401774
- Ages
- 18 Years – 99 Years
- Sexes
- All
- Location
- Jacksonville
OPEN ENROLLMENT
Use of AC through Provider Prompting about Oral AC Therapy for AF (SUPPORT-AF) IV
This study is multifaceted and has multiple aims. 1. Discover what role religiosity and spirituality play in anticoagulant (AC) use in non-white older adults with atrial…
- Investigator
- Luis Ortega Paz
- IRB Number
- CED000000646
- Ages
- 18 Years – 99 Years
- Sexes
- All
- Location
- Jacksonville
OPEN ENROLLMENT
ABCD Gene Substudy
Blood thinning medications prevent cells in the body called platelets from sticking together that would lead to a clot and subsequent heart attacks. Dual blood thinning therapy with aspirin and…
- Investigator
- Francesco Franchi
- IRB Number
- IRB202302083
- Ages
- 18 Years – 99 Years
- Sexes
- All
- Location
- Jacksonville
OPEN ENROLLMENT
A Study of Contrast-induced Acute Kidney Injury Prediction Using the RENISCHEM L-FABP Assay at the Point-of-Care (SAKURA-POC)
The purpose of this research is to help doctors and scientists learn about an investigational test called RENISCHEM L-FABP Test. This test looks for a substance in urine that can help doctors…
- Investigator
- Dominick Angiolillo
- IRB Number
- 20212233
- Ages
- 18 Years – 99 Years
- Sexes
- All
- Location
- Jacksonville
OPEN ENROLLMENT
SWAP 7
You are being asked to participate in this study because you have a stent in your heart artery for at least 90 days and you are currently taking blood-thinning medications as part of your standard of…
- Investigator
- Francesco Franchi
- IRB Number
- IRB202401578
- Ages
- 18 Years – 99 Years
- Sexes
- All
- Location
- Jacksonville
OPEN ENROLLMENT
SWAP 8
People are being asked to participate in this study because they have a stent in their heart artery and are currently taking blood-thinning medications as part of standard of care. In particular,…
- Investigator
- Luis Ortega Paz
- IRB Number
- IRB202401735
- Ages
- 18 Years – 99 Years
- Sexes
- All
- Location
- Jacksonville
OPEN ENROLLMENT
SWAP 9
People are considered for participation in this trial when. they are taking two blood-thinning medications, which include baby aspirin plus either Prasugrel (Effient) or Ticagrelor (Brilinta)….
- Investigator
- Luis Ortega Paz
- IRB Number
- IRB202400929
- Ages
- 18 Years – 99 Years
- Sexes
- All
- Location
- Jacksonville
Early Feasibility Study of the Edwards Transcatheter Atrial Shunt System
In patients with left heart failure, elevations in left atrial pressures can also cause pressure elevations in blood vessels between the left atrium and the lungs resulting in a condition called…
- Investigator
- Dominick Angiolillo
- IRB Number
- 20181035
- Ages
- 18 Years – 99 Years
- Sexes
- All
- Location
- Jacksonville
OPEN ENROLLMENT
Dal-Gene-2
Events such as myocardial infarction (heart attack) or the need for a revascularization procedure (implantation of a stent in a coronary artery) are signs of severe arterial disease. Events such as…
- Investigator
- Dominick Angiolillo
- IRB Number
- 20233015
- Ages
- 45 Years – 99 Years
- Sexes
- All
- Location
- Jacksonville
OPEN ENROLLMENT
AMPLITUDE
This study is being done to learn more about the safety and effectiveness of the investigational drug VX-147 in participants with APOL1-Mediated Chronic Kidney Disease. People of recent…
- Investigator
- Dominick Angiolillo
- IRB Number
- 20233313
- Ages
- 18 Years – 65 Years
- Sexes
- All
- Location
- Jacksonville